Clarity™ Digital PCR System

Information

Clarity™ digital PCR system offers a new paradigm in the absolute quantification of target nucleic acids with
high precision, accuracy and sensitivity.

The tube-strip format simplifies the cumbersome workflow typically a ssociated with digital PCR by making
it quick and easy to load, partition, thermal cycle and detect the reactions. The unique chip-in a-tube design
combines the robustness of chip-based partitioning with the ease-of use of a tube-strip. Each PCR mix is
rapidly subdivided into 10,000 partitions by a high-density chip within each tube. The high-density chip
allows a large number of partitions to exist within the small confines of a PCR tube. Up to 8 reactions can be
run in parallel to yield 80,000 partitions per tubestrip. Clarity™ tube-strips are compatible with most
conventional thermal cyclers to allow up to 96 digital PCR reactions per run.

Key Application

  • CLARITY™ AUTO LOADER: 10,000 partitions per tube, 8 reactions partitioned per tube-strip within 1
    min, Small footprint & lightweight, Performs up to 96 digital PCR reactions per run.
  • CLARITY™ SEALING ENHANCER: Eliminates cross contamination between the high density partitions,
    Automated, Minimal hands on time, Small footprint, 8 reactions at a time.
  • CLARITY™ READER: Stand-alone, Reads 4 tube-strips or 32 reactions, 2-color: FAM™/SYBR®/
    EvaGreen® and VIC®/HEX™, Automated, Walk away, operation, Closed tube.
  • CLARITY™ SOFTWARE: Performs analysis of the digital PCR tube-strips from any computer, provides
    enhanced, functionality when, connected to Reader, Results generated on the fly while Reader is still in
    progress, Results and graphs easily exported.

Application Area

  • Accurate quantification of Illumina® NGS libraries.
  • Copy Number Variation Analysis
  • Food adulteration detection
  • Rare mutation detection
  • Pathogen/ virus detection
  • Gene expression

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